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December 4, 2025Pharmacognosy MagazineOpen Access

Matairesinol Shows Neuroprotective Activity Against Cerebral Ischemia/Reperfusion Injury via Downregulating TLR4-NLRP3 Inflammasome Pathway

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Authors

HZHongyan ZhangKZKun Zhang

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Overview

Animal studies show matairesinol reduces brain edema and inflammatory cytokines in ischemic stroke, suggesting new therapeutic potential.

Key Points

  • Oral pretreatment with matairesinol reduced brain edema and improved neurological scores in rats with ischemic stroke.
  • Inflammatory cytokine levels significantly declined post-treatment, along with reductions in acetylcholinesterase concentrations.
  • Middle cerebral artery occlusion was used to induce ischemia/reperfusion injury in experimental rats for assessment of treatment effects.
  • These findings highlight the potential of matairesinol as a novel therapy for ischemic stroke, warranting further investigation.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca2392https://doi.org/10.1177/09731296251396330
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