Abstract 3: Hospitalizations for Malignant Pancreatic Neoplasms in Brazil: An Epidemiological Analysis from 2019 to 2023

Abstract Purpose: Pancreatic cancer, a malignancy with a high mortality rate, has shown an increase in incidence in Brazil, particularly in the Southern and Southeastern regions of the country. Understanding epidemiological trends and risk factors is essential for guiding preventive interventions, screening strategies, and the development of predictive models, with the goal of reducing the impact of this disease with a poor prognosis. Therefore, this study aims to analyze and compare the epidemiological profile of hospitalizations due to malignant pancreatic neoplasms in Brazil from 2019 to 2023 and identify the main associated factors. Methods: This is a cross-sectional, descriptive, and quantitative study based on data from the Department of Informatics of the Unified Health System (DATASUS), analyzing hospitalizations due to malignant pancreatic neoplasms in Brazil from 2019 to 2023. The study included variables such as age group, sex, race/ethnicity, mortality rate, and average length of stay. Results: Between 2019 and 2023, there were 75, 201 hospitalizations due to malignant pancreatic neoplasms in Brazil, with nearly equal distribution between men (50. 1%) and women (49. 8%). The Southeast region recorded the highest number of hospitalizations (34, 323), followed by the South (19, 903), Northeast (13, 006), Central-West (5, 625), and North (2, 344). Most cases occurred in individuals aged 60 to 79, accounting for 54. 7% of the total. In terms of race/ethnicity, 48. 1% were White, 35. 1% were Mixed race, and 5. 0% were Black. The average hospital stay was 6. 4 days, with the longest duration in the North (8. 7 days). The overall mortality rate was 21. 11%, with the North region exhibiting the highest rate (24. 96%). Conclusion: The data reveal significant regional disparities in Brazil, with a demographic profile predominantly of elderly and white patients, at higher risk for poor disease progression. The high mortality rate associated with pancreatic neoplasms reinforces the poor prognosis of pancreatic neoplasms, underscoring the need for early screening, especially in the most affected regions. Longer hospital stays in the North suggest gaps in access to early diagnosis and treatment, worsening patient outcomes. These findings are essential for guiding public policies focused on prevention, early diagnosis, and oncological support to reduce disparities and improve health outcomes. Citation Format: João Paulo Farezin Fortti, Gabriela Pereira Macelaro. Hospitalizations for Malignant Pancreatic Neoplasms in Brazil: An Epidemiological Analysis from 2019 to 2023 abstract. In: Proceedings of the 13th Annual Symposium on Global Cancer Research; 2025 Sep 16. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34 (12Suppl): Abstract nr 3.