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December 4, 2025Scientific ReportsOpen Access

Pathway-dependent cold activation of heat-responsive TRPV channels

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Authors

GWGuangyu Wang

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Overview

Computational study confirms thermal sensors and pathways for TRPV1 and TRPV4, highlighting distinct activation mechanisms.

Key Points

  • Cold activation depended on thermal sensor pathways found in TRPV1 and TRPV4, demonstrating unique activation mechanisms.
  • Key findings revealed that disrupting intersubunit interactions was essential for channel opening, differing by TRPV type.
  • Observational analysis compared cold activation in minimal TRPV1 with full-length human TRPV3 and their distinct pathways.
  • Research may lead to a better understanding of TRPV channel roles, aiding in thermoregulation and sensory response.

Cite This Study

Guangyu Wang (2025) studied this question.

synapsesocial.com/papers/6930dc81ea1aef094cca252chttps://doi.org/10.1038/s41598-025-29524-y
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