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March 28, 2026Scientific ReportsOpen Access

Temperature-dependent gating pathways in TRPV3

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Authors

GWGuangyu Wang

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Overview

Examines temperature-sensitive mechanisms in TRPV3 channels, suggesting shared pathways for heat and cold responses.

Key Points

  • The aim is to explore how temperature affects the function and structure of TRPV3 channels, particularly in relation to inactivation.
  • Characterized TRPV3 structures at varying temperatures
  • Examined the effects of tetrahydrocannabivarin (THCV) on TRPV3 gating
  • Conducted thermoring analyses on oxidized TRPV3
  • Analyzed lipid-dependent gating pathways
  • TRPV3 is activated and inactivated by THCV below 30 °C
  • Inactivation does not occur above 30 °C when THCV binds
  • Cold and heat activation pathways exhibit similar thermosensitivity
  • Inactivation is linked to pore dilation and changes in channel structure

Cite This Study

Guangyu Wang (2026) studied this question.

synapsesocial.com/papers/69c7722a8bbfbc51511e2619https://doi.org/10.1038/s41598-026-44194-0
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