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December 4, 2025TrialsOpen Access

SurfON trial: study protocol for a multicentre, open-label, randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress

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Authors

CCChristina ColeIMIndrani ManoharanHOHeather O’Connor

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Overview

Randomised controlled trial compares early surfactant therapy to expectant management in preterm infants, highlighting potential cost-effectiveness and perinatal outcomes.

Key Points

  • Early surfactant therapy improves respiratory outcomes in late preterm and early term infants, suggesting better hospital stays.
  • The trial involves 45 UK neonatal units aiming for 1522 neonates over 30 months, with open-label methods implemented.
  • Eligible infants are those requiring noninvasive respiratory support for respiratory distress post-birth.
  • Results may guide evidence-based management of respiratory issues in preterm neonates and minimize family distress.

Cite This Study

Cole et al. (2025) studied this question.

synapsesocial.com/papers/6930dc81ea1aef094cca25dchttps://doi.org/10.1186/s13063-025-09271-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates2024 · 2 citations
  2. 2Minimally Invasive Surfactant Therapy Versus InSurE in Preterm Neonates of 28-34 Weeks of Gestation with Respiratory Distress Syndrome: A Randomised Controlled Trial2026
  3. 3<scp>EBNEO</scp> commentary: Surfactant administration via laryngeal mask airway versus brief tracheal intubation in preterm infants2024 · 2 citations
  4. 45988 Surfactant administration in neonates- present practises and future trends2024
  5. 5Prospective, non-blinded, randomized controlled trial on early administration of pulmonary surfactant guided by lung ultrasound scores in very preterm infants: study protocol2024 · 5 citations