December 4, 2025AntibioticsOpen Access

Evaluation of the Quantitative and Structural Antimicrobial Activity of Thymol, Terpinen-4-ol, Citral, and E-2-Dodecenal, Antibiotic Molecules Derived from Essential Oils

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Very good antimicrobial activity was observed for all molecules at levels below 500 µg/mL.
The minimum inhibitory concentration was determined using the micro dilution in plates method across several microorganisms.
Structural observations were conducted using Optical Microscopy and Scanning Electron Microscopy to assess cell membrane damage.
Antimicrobial activity indicates potential for essential oils as natural alternatives for antibiotic treatments.

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Evaluation reveals antimicrobial activity of essential oil components in microorganisms, suggesting structural damage impacts efficacy.

Noriega et al. (2025) studied this question.

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