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December 4, 2025BMC Pregnancy and ChildbirthOpen Access

Maternal and neonatal outcomes in women undergoing trial of labor after cesarean (TOLAC) compared with elective repeat cesarean section (ERCS): a cohort study

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Authors

GBGregory Bierry

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Overview

Cohort study shows lower rates of severe postpartum hemorrhage and NICU admissions in TOLAC compared to elective repeat cesarean.

Key Points

  • Severe postpartum hemorrhage occurred less frequently in the TOLAC group at 5.6% compared to 10.4% in the ERCS group, indicating a significant reduction in risk.
  • Statistical analysis employed chi-square tests and Student’s t-tests to assess differences between delivery methods, confirming findings of the adjusted model.
  • Among 2,424 women analyzed, neonatal intensive care unit admissions were lower for TOLAC at 6.5% versus 13.3% for ERCS, supporting TOLAC's safety.
  • Implying TOLAC may be a safe option, the results highlight potential benefits in severe maternal outcomes despite slight risks related to uterine rupture.

Cite This Study

Gregory Bierry (2025) studied this question.

synapsesocial.com/papers/6930dc8aea1aef094cca27fbhttps://doi.org/10.1186/s12884-025-08447-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal and perinatal outcome in trial of labour after caesarean at tertiary care hospital: a prospective observational study2020 · 1 citations
  2. 2Trial of Labor After Cesarean and Vaginal Birth After Cesarean: A Systematic Review and Meta-Analysis of Maternal and Neonatal Outcomes2026
  3. 3Risks and Probabilities of Adverse Pregnancy Outcomes in Patients Undergoing Trial of Labor after Cesarean—A Retrospective Study2024
  4. 4Trial of labour after two caesarean sections (TOLA2C) and risk of uterine rupture, a retrospective single centre study2024
  5. 5Nine years' experience of trial of labor after two previous cesarean sections at a tertiary hospital – A retrospective cohort study2026