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December 4, 2025Journal of Pharmacology and PharmacotherapeuticsOpen Access

Pharmacological Strategies in Cancer Immunotherapy: Advancing Immune Checkpoint Inhibitors, CAR-T Cell Therapies, and Cancer Vaccines

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Authors

PYPankaj YadavUniversity of DelhiBTBhishmani TarareGovernment Ayurved College, Nanded

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Overview

This review analyzes immune checkpoint inhibitors and CAR-T cell therapies in cancer patients, suggesting its potential to enhance treatment efficacy.

Key Points

  • Cancer vaccines and CAR-T cell therapies are critical strategies that may improve responses in non-small-cell lung cancer and melanoma.
  • The use of immune checkpoint inhibitors such as CTLA-4 and programmed cell death protein 1 has shown effectiveness against diverse cancer types.
  • An overview of recent clinical trials on cancer immunotherapy reveals promising outcomes in overcoming resistance mechanisms.
  • Future research should focus on optimizing combination treatments and expanding applications of immunotherapeutics in oncology.

Cite This Study

Yadav et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca294ahttps://doi.org/10.1177/0976500x251398611
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Current Advances in Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, and Future Perspectives2026
  2. 2Immune-based cancer therapies: mechanistic insights, clinical progress, and future directions2025 · 9 citations
  3. 3The Role of Immunotherapy in Cancer Treatment: Mechanisms, Efficacy, and Future Directions2024
  4. 4Next generation approaches in cancer immunotherapy targeting mechanisms beyond PD1 and PDL12026 · 2 citations
  5. 5Emerging trends in immunotherapy and cancer pharmacology: Exploring novel therapeutic approaches in oncology2026