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This research demonstrates enhanced Zn 2+ detection in living cells using a novel fluorescent probe, indicating potential for environmental applications.
A novel salicylaldehyde‐benzohydrazide–based fluorescent probe L was designed and synthesized. The probe displayed excellent specificity and sensitivity for Zn 2+ detection in aqueous media (HEPES buffer, pH = 7.40), accompanied by a remarkable colorimetric fluorescence change from colorless to green under a 365 nm UV lamp. The detection mechanism of probe L for Zn 2+ was elucidated by 1 H NMR, HRMS, and DFT calculation. Moreover, the probe was effectively applied in the detection of Zn 2+ in both environmental samples and biological imaging in living cells.
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Yang et al. (2025) studied this question.
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