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December 4, 2025Psychiatry and Clinical Neurosciences

Higher discontinuation with dual orexin receptor antagonists than with benzodiazepines: A Japanese claims cohort study

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Authors

ASAkiyoshi ShimuraTokyo Medical University KMKentaro MatsuiNational Cancer Centre Japan YTYoshikazu TakaesuUniversity of the Ryukyus

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Implication

Cohort analysis reveals dual orexin receptor antagonists have higher discontinuation rates than benzodiazepines, suggesting specific patient considerations.

Key Points

Dual orexin receptor antagonists demonstrate a higher likelihood of discontinuation compared to benzodiazepines.
Kaplan–Meier analysis showed significant differences among hypnotic classes (P < 0.001).
Cox proportional hazards analysis provided a hazard ratio of 1.40 for discontinuation of dual orexin receptor antagonists versus benzodiazepines.
Findings imply clinical considerations for prescribing dual orexin receptor antagonists may be necessary in insomnia treatment.

Cite This Study

Shimura et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2ab9 https://doi.org/10.1111/pcn.70004

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Implication

Cohort analysis reveals dual orexin receptor antagonists have higher discontinuation rates than benzodiazepines, suggesting specific patient considerations.

Higher discontinuation with dual orexin receptor antagonists than with benzodiazepines: A Japanese claims cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

Higher discontinuation with dual orexin receptor antagonists than with benzodiazepines: A Japanese claims cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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