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December 4, 2025Journal of Viral HepatitisOpen Access

Modelling Micro‐Elimination: Third‐Trimester Tenofovir Prophylaxis for Perinatal Transmission of Hepatitis B in the Remote Dolpa District of Nepal

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Authors

BTBelaynew Wasie TayeSAShrestha Ananta

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Overview

Mathematical modelling shows third-trimester tenofovir reduces hepatitis B burden in pregnant women, suggesting effective intervention for elimination.

Key Points

  • Hepatitis B burden significantly lowers with increased tenofovir coverage and vaccination efforts in Dolpa district.
  • Mathematical modelling predicts potential elimination of hepatitis B in children by 2045 with specific intervention strategies.
  • Observational analysis of intervention scenarios reveals reduced morbidity and mortality linked to hepatitis B.
  • Implementation of micro-elimination strategies may address challenges in remote locations, supporting equitable health access.

Cite This Study

Taye et al. (2025) studied this question.

synapsesocial.com/papers/6930dc9eea1aef094cca2cabhttps://doi.org/10.1111/jvh.70110
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  2. 2Tenofovir Disoproxil Fumarate Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Comprehensive Assessment from the Systematic Review and Meta-Analysis2025
  3. 3Eliminating perinatal transmission of hepatitis B virus: it is time for action2024 · 3 citations
  4. 4Hepatitis B in pregnancy and breastfeeding: current approaches to prophylaxis and treatment2026
  5. 5Evaluation of the Efficacy and Safety of Tenofovir Disoproxil Fumarate in Intercepting Mother-to-Child Transmission of Hepatitis B Virus.2024 · 1 citations