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December 4, 2025MedicineOpen Access

Effect of immune cells and plasma metabolites on inflammatory bowel disease: Two-sample Mendelian randomization study and mediation analysis

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Authors

HWHaiyan WenHXHuang Xiao-hong

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Overview

Mendelian randomization analysis shows immune cells influence inflammatory bowel disease, suggesting metabolic targets for treatment.

Key Points

  • Mendelian randomization shows immune cells are causally linked to inflammatory bowel disease and its subtypes.
  • Analysis involved 731 immune cell types and 1400 plasma metabolites, identifying connections to Crohn's and ulcerative colitis.
  • Methodology included sensitivity analysis and mediation analysis to uncover key metabolic roles in immune responses.
  • Findings highlight potential metabolic pathways for managing inflammatory bowel disease, warranting further exploration.

Cite This Study

Wen et al. (2025) studied this question.

synapsesocial.com/papers/6930dc9eea1aef094cca2d2ahttps://doi.org/10.1097/md.0000000000046116
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