In-silico and In-vivo investigation of ameliorative potential of Mucuna pruriens L. seeds’ on Bisphenol A-induced testicular toxicity in male mice

Male Infertility due to diminished testosterone is one of the most common issues in the present-day scenario. Treating reproductive failure by enhancing the 3betaHSD and 17betaHSD can resolve this problem easily. There are various medicines readily available in the market that can aid in the steroidogenesis and thus, increases the spermatogenesis of an individual. But such medicines might have side effects in the long run and thus a cost-effective solution bereft of any side-effect is required. Medicinal plants have bioactive compound that can provide us the solution. In this piece of experimental work, the methanolic extract of Mucuna pruriens seeds were administered in a BPA-induced model of mice with reproductive toxicity. The extract was found to elevate the total cholesterol, lipid and protein levels in testis. Apart from that it was shown to directly enhance the 3betaHSD and17betaHSD which also results in the testosterone level increase. Traditionally this plant has been used by the tribals of north eastern India with the belief that it increases male fertility. The laboratory work has suggested similar results as MeMP has increased the fertility indices of the male mice by regulating the steroidogenic process. In-silico studies have suggested that certain compounds of this seed extract have drug likeliness and a good binding affinity as per the CC-standard drug.