Late-Stage Peptide Modification with Salicylaldehyde Tag Enhances Affinity for Nuclear Factor-kappa B Essential Modulator

Damiano Rondelli; Luca Pignataro; Laura Belvisi

doi:10.1039/d5cb00282f

January 1, 2025RSC Chemical BiologyOpen Access

Late-Stage Peptide Modification with Salicylaldehyde Tag Enhances Affinity for Nuclear Factor-kappa B Essential Modulator

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Key Points

Salicylaldehyde modification enhances ligand affinity for nuclear factor-kappa B essential modulator, NEMO.
Affinity improvement indicates greater potential to engage target proteins effectively.
Approach involves late-stage functionalization with salicylaldehyde tags to create versatile ligands.
Suggests that reversible-covalent interactions may offer innovative therapeutic strategies.

Implication

Late-stage peptide modification enhances affinity for NEMO, suggesting potential for reversible-covalent ligand development.

Abstract

The late-stage peptide functionalization with salicylaldehyde (SA) tags is described here as a versatile design of potential Lys-engaging, reversible-covalent ligands. This approach was applied to a known binder for NEMO,...

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Cite This Study

Rondelli et al. (2025) studied this question.

synapsesocial.com/papers/6930dc9eea1aef094cca2e12 https://doi.org/10.1039/d5cb00282f

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Late-Stage Peptide Modification with Salicylaldehyde Tag Enhances Affinity for Nuclear Factor-kappa B Essential Modulator

Key Points

Implication

Abstract

Discussion

Cite This Study

Late-Stage Peptide Modification with Salicylaldehyde Tag Enhances Affinity for Nuclear Factor-kappa B Essential Modulator

Key Points

Implication

Abstract

Discussion

Cite This Study

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