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December 4, 2025APL MaterialsOpen Access

3D-printed oxygen-releasing scaffolds promote bone repair via angiogenesis and osteogenesis

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Authors

PLPengyuan LengCSChuchu Sun

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Overview

3D-printed scaffolds improved bone regeneration in a rat model, suggesting that oxygen release aids healing.

Key Points

  • Bone regeneration was significantly enhanced by oxygen-releasing 3D-printed scaffolds, promoting angiogenesis and osteogenesis.
  • Mechanical properties and sustained oxygen release for over three weeks were observed in polycaprolactone and hydroxyapatite scaffolds.
  • Fused deposition modeling was utilized to create scaffolds to test their effects on rat bone marrow mesenchymal stem cells.
  • This approach may highlight potential advancements in tissue engineering for clinical use in bone repair.

Cite This Study

Leng et al. (2025) studied this question.

synapsesocial.com/papers/6930dc9eea1aef094cca2e17https://doi.org/10.1063/5.0305073
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxygen-enhanced 3D-printed scaffolds for repair of ischemic bone2025
  2. 2Designing for Growth: Structural Insights into 3D-Printed Composite Scaffolds for Bone Repair.2026
  3. 33D-Printed Composite Scaffolds Containing SiO <sub>2</sub> for Bone Regeneration in <i>In Vivo</i> Models: A Systematic Review2026
  4. 43D-printed zinc/magnesium-doped hydroxyapatite-polycaprolactone composite scaffolds for angiogenesis and osteogenesis2024 · 10 citations
  5. 5Combining three-dimensionality and CaP glass-PLA composites: Towards an efficient vascularization in bone tissue healing2024 · 9 citations