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December 4, 2025Nature MetabolismOpen Access

Fat sensory cues in early life program central response to food and obesity

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Authors

MMMouna El MehdiJBJanice BulkLRLionel Rigoux

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Overview

Findings reveal maternal obesity programs food responses in offspring, suggesting fat cues impact metabolic health.

Key Points

  • Offspring exposed to fat sensory cues show increased adiposity and metabolic diseases later in life.
  • Dopaminergic circuits respond differently to food in the context of maternal obesity, indicating alterations in metabolic health.
  • Developmental exposure to dietary fat cues significantly impacts central responses to food intake and overall metabolism.
  • Findings highlight the role of early-life sensory experiences in programming obesity risk and metabolic disorders.

Cite This Study

Mehdi et al. (2025) studied this question.

synapsesocial.com/papers/6930e8b6ea1aef094cca2ee6https://doi.org/10.1038/s42255-025-01405-8
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