December 4, 2025PLoS ONEOpen Access

Integrated single-cell RNA-seq and bulk RNA-seq analysis to investigate key adipogenesis genes in adipose-derived stem cells

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ZCZhongming CaiChinese Academy of Medical Sciences & Peking Union Medical College LGLeijuan GanChinese Academy of Medical Sciences & Peking Union Medical College

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Integrating single-cell and bulk RNA-seq identifies differentiation regulators in adipose-derived stem cells, suggesting targets for improving adipocyte stability.

Key Points

Differentiation of adipose-derived stem cells plays a crucial role in adipose tissue homeostasis and clinical applications.
The integration of single-cell and bulk RNA-seq revealed key regulators of differentiation in adipose-derived stem cells.
Stage-specific transcriptional regulators were validated and associated with lipid metabolism and energy regulation during differentiation.
These findings may enable the development of strategies to modulate adipocyte differentiation and stability.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/6930e8b6ea1aef094cca307d https://doi.org/10.1371/journal.pone.0335152

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Implication

Integrating single-cell and bulk RNA-seq identifies differentiation regulators in adipose-derived stem cells, suggesting targets for improving adipocyte stability.

Integrated single-cell RNA-seq and bulk RNA-seq analysis to investigate key adipogenesis genes in adipose-derived stem cells

Discussion

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Implication

Key Points

Cite This Study

Integrated single-cell RNA-seq and bulk RNA-seq analysis to investigate key adipogenesis genes in adipose-derived stem cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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