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December 4, 2025PLoS ONEOpen Access

Hematocrit in the first 2 hours of life and short-term outcomes in very preterm infants: A secondary analysis from a prospective cohort study

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Authors

YTYeow Leng TanNJNing Jiang

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Overview

Prospective cohort study reveals hematocrit affects transfusion needs and late-onset sepsis in very preterm infants, indicating its clinical importance.

Key Points

  • Higher hematocrit levels in the first two hours of life are linked to reduced late-onset sepsis and transfusion needs.
  • Infants with hematocrit levels of 45 or more had lower odds of retinopathy of prematurity and transfusion needs.
  • Data analysis was performed using multivariable logistic regression to assess significant outcomes.
  • Findings suggest a key role for early hematocrit assessments in managing very preterm infants, though further research is warranted.

Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/6930e8b6ea1aef094cca30e5https://doi.org/10.1371/journal.pone.0336601
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between Hematocrit in the First Two Hours of Life and Retinopathy during Prematurity: A Retrospective Study from DRYAD2024
  2. 2The Early Hematological Profile and Its Variations: A Useful Tool in the Prediction of Intraventricular Hemorrhage in Extremely Preterm Infants2024 · 1 citations
  3. 3From Blood Count Parameters to ROP Risk: Early Hematological Predictors in Preterm Infants2025
  4. 4The Plateletcrit and Hematocrit Levels in Premature Infants with Intraventricular Hemorrhage2025
  5. 5Postoperative Hematocrit and Lactate Trajectory After Neonatal Cardiopulmonary Bypass: A Retrospective Cohort Study2026