Propofol Alleviates Depression‐Like Behavior and Cognitive Disorder in Learned Helplessness Model Mice via Regulating Synaptic Function

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Propofol alleviates depressive behaviors and improves cognitive function in a learned helplessness model.
Notably, treated mice showed enhanced neurogenesis and synaptic function related to the Notch signaling pathway.
Behavioral analyses included tail suspension test and other methods to evaluate depression-like impairment.
The findings imply propofol's potential as an antidepressant that merits further investigation for clinical use.

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Propofol reduces depression-like symptoms and enhances neurogenesis in C57BL/6j mice, suggesting potential antidepressant effects.

Wang et al. (2025) studied this question.

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