Preclinical pilot study shows improved myocardial recovery in a porcine model with IGL-2, highlighting reduced endothelial injury and oxidative stress.
Background Hypothermic ex situ heart graft perfusion using acellular preservation solution is a promising technique for heart transplantation. Methods We investigated the cardioprotective effects of a novel preservation solution, IGL‐2 (Institut Georges Lopez, France), in a porcine model of hypothermic ex situ heart perfusion over 4 h, following either beating‐heart procurement or donation after circulatory death. Results Coronary endothelial injury (assessed by Endothelin‐1) and oxidative stress markers (assessed by nitrates and hydrogen peroxide) were evaluated through repeated perfusate sampling. Cardiac power output was measured after ex situ warm reperfusion in working mode. Conclusion Preservation with IGL‐2 was associated with reduced endothelial injury and oxidative stress, resulting in improved myocardial recovery following blood reperfusion.
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Van et al. (2025) studied this question.
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