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Observational analysis reveals blood cancer risk linked to clonal hematopoiesis in 9/11 first responders, indicating exposure to particulate matter may exacerbate conditions.
Summary: In this issue, Verma, Zeig-Owens, Goldfarb, and colleagues report that increased prevalence of clonal hematopoiesis (CH) among 9/11 World Trade Center first responders is accompanied by uncharacteristic mutations in younger responders and an elevated risk of blood cancer. Using a mouse model of CH, they connect the clonal expansion triggered by World Trade Center particulate matter exposure to higher levels of IL1RAP, offering a new potential target to limit clonal expansion and reduce CH-associated risks. See related article by Verma et al., p. 2468
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Safina et al. (2025) studied this question.
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