Acute Lead Exposure Weakens Myocardial Contractile Function and the Therapeutic Effect of Alpha Lipoic Acid

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Acute lead exposure significantly inhibited cardiac contractile function, reducing heart rate and contraction amplitude.
Lead acetate decreased amplitude of heart contractions to 69.7% and reduced heart rate to 54.9% in toad hearts.
Alpha lipoic acid at 10 μM improved cardiac function, increasing myocardial contraction by 109.4% and heart rate by 134.2%.
Results highlight alpha lipoic acid's potential as a cardioprotective agent against lead-induced injury.

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Acute lead exposure inhibited cardiac function in toad hearts, suggesting alpha lipoic acid may protect myocardial health.

Zhou et al. (2025) studied this question.

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