Circulating plasma cell heterogeneity appears to be crucial for understanding multiple myeloma progression, helping to detect disease early.
The incidence of the D | CD138 | BCMA-Memb phenotype significantly increases from monoclonal gammopathy of undetermined significance to overt multiple myeloma.
Observational analysis involving multi-channel immunofluorescence staining and machine learning revealed distinct circulating plasma cell subpopulations across disease states.
Findings hint at the potential of liquid biopsy to enhance early diagnosis and treatment monitoring for multiple myeloma.