Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study.

Yixin Ma; Lubin Xu; Yitao Lin; Jiahao Zhu; Jin Liu; Li Wang; Li-Meng Chen

doi:10.1159/000548430

December 1, 2025

Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study.

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Key Points

Renal outcomes are significantly influenced by endothelial vasoactive pathways, indicating potential therapeutic targets.
The study demonstrates a connection between vasoactive pathways and CKD management outcomes.
This analysis employed the method of Mendelian randomization to evaluate metrics of kidney health.
Research highlights the potential for targeted therapies based on these endothelial pathways in chronic kidney disease.],

Implication

Observational analysis found significant impact of endothelial vasoactive pathways on renal outcomes, suggesting targeted therapies may improve CKD management.

Abstract

Our results shed light on a significant effect of endothelial vasoactive pathways in kidney-related outcomes, which hold promise for alternative targeted therapies in CKDs.

Discussion

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Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/6930e8cdea1aef094cca384d https://doi.org/10.1159/000548430

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Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study.

Key Points

Implication

Abstract

Discussion

Cite This Study

Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study.

Key Points

Implication

Abstract

Discussion

Cite This Study

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