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Identify novel therapeutic protein targets for chronic kidney disease and related renal function traits using proteome-wide genetic analyses.

September 27, 2024Scientific ReportsOpen Access

Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease

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Identify novel therapeutic protein targets for chronic kidney disease and related renal function traits using proteome-wide genetic analyses.
Analyzed genetic associations for 4,657 plasma proteins measured in 7,213 European American individuals from the ARIC study.
Integrated genome-wide association study datasets for chronic kidney disease (N=765,348), creatinine-based eGFR (N=1,004,040), and eGFR (N=567,460) using Mendelian randomization and genetic colocalization.
Genetically predicted elevations in circulating Transcription elongation factor A protein 2 (TCEA2) and Neuregulin-4 (NRG4) were associated with decreased risk of chronic kidney disease.
Genetically predicted higher levels of Glucokinase regulatory protein (GCKR) were associated with increased chronic kidney disease risk, with colocalization supporting shared causal signals across eGFR traits.

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Implication

Mendelian randomization study uncovers three causal protein targets for chronic kidney disease in diverse populations, highlighting potential avenues for targeted drug development.

Cite This Study

Zhao et al. (2024) studied this question.

synapsesocial.com/papers/6aae2f340e76cf58d1b693d8 https://doi.org/10.1038/s41598-024-72970-3

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Implication

Mendelian randomization study uncovers three causal protein targets for chronic kidney disease in diverse populations, highlighting potential avenues for targeted drug development.

Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease

Key Points

Discussion

Implication

Cite This Study

Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease

Key Points

Discussion

Implication

Cite This Study

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