Waterpipe Smoke-Induced N6-Methyladenosine Modification Promotes the Progression of Oral Squamous Cell Carcinoma

Prathibha Prasad; Mohamed Jaber; Al Moutassem Billah Khair; Musab Hamed Saeed; Abilasha Ramasubramanian; Paramasivam Arumugam

doi:10.1016/j.identj.2025.109295

November 29, 2025International Dental JournalOpen Access

Waterpipe Smoke-Induced N6-Methyladenosine Modification Promotes the Progression of Oral Squamous Cell Carcinoma

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Key Points

N6-methyladenosine modification enhances oral cancer progression and improves patient outcomes.
Key evidence shows elevated METTL3 levels in oral squamous cell carcinoma linked to waterpipe exposure.
This analysis highlights the role of HMGA2 in cancer progression linked to smoking habits.
Findings suggest targeting METTL3 could provide new strategies for therapeutic intervention in oral cancer. “],

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Implication

Findings reveal N6-methyladenosine modification promotes oral cancer progression, suggesting METTL3 as a therapeutic target for waterpipe smokers.

Abstract

Elevated levels of METTL3 induced by waterpipe smoke lead to OSCC progression via HMGA2 and EMT, highlighting METTL3 as a potential biomarker and therapeutic target in OSCC caused by smoking.

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Cite This Study

Prasad et al. (2025) studied this question.

synapsesocial.com/papers/6930e8cdea1aef094cca387b https://doi.org/10.1016/j.identj.2025.109295

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Waterpipe Smoke-Induced N6-Methyladenosine Modification Promotes the Progression of Oral Squamous Cell Carcinoma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Waterpipe Smoke-Induced N6-Methyladenosine Modification Promotes the Progression of Oral Squamous Cell Carcinoma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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