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December 4, 2025Advanced Materials

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

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Authors

SKSung Hoon KimWCWonseok ChoiYKYurim Kim

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Overview

Platform demonstrates improved antigen presentation at tumor sites using hydrogels and ultrasound, suggesting potential for immunotherapy in cancer treatment.

Key Points

  • Immunotherapy enhances therapeutic efficacy by targeting immune deserts, leading to improved anti-cancer responses.
  • Platform integrates cancer vaccines with adjuvants, enhancing T cell infiltration and antigen presentation at tumor sites.
  • Assessment using hydrogel-assisted histotripsy shows localized activation of immunostimulatory agents, with significant immune response.
  • Potential impact includes enhancing antitumor immunity, addressing immunosuppressive microenvironments in cancer patients.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3a2dhttps://doi.org/10.1002/adma.202518245
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: <i>Immunoasis</i> (Adv. Mater. 22/2026)2026
  2. 2Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity2024 · 36 citations
  3. 3A Programmable Peptidic Hydrogel Adjuvant for Personalized Immunotherapy in Resected Stage Tumors2024 · 18 citations
  4. 4Abstract 3735: Combinatorial targeting of tumor-microenvironment together with antigen vaccination using innovative nano-immuno-gel for enhanced cancer-immunotherapy2024
  5. 5Stimuli-Responsive Hydrogel Platforms for Cancer Immunotherapy: Advances in Design, Mechanisms, and Clinical Translation2026