Analysis shows SIRT5 regulation affected by reduced nicotinic acid riboside, suggesting implications for metabolic processes.
SIRT5, one of the human sirtuins, catalyzes the removal of acyl substitutions from lysine residues in a NAD +-dependent manner. In addition to the deacetylase activity, SIRT5 also demonstrates strong desuccinylase,...
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Hamza et al. (2025) studied this question.
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