Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7

Nurgül Bilgin; Laust Moesgaard; Jacob Kongsted; Jasmin Mecinović

doi:10.1039/d5sc08094k

January 1, 2025Chemical ScienceOpen Access

Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7

View Full Paper

Ask AI

Bookmark

Share

Key Points

Methylation impacts H3K4, influencing gene expression.
Key modification by lysine methyltransferase SETD7 identified.
This research underscores the significance of epigenetic control in gene regulation.
The findings could enhance understanding of gene expression mechanisms.

Implication

Analysis reveals the role of epigenetic control in eukaryotic gene expression through SETD7 activity.

Abstract

The SETD7-catalysed methylation of lysine 4 in histone 3 (H3K4) plays an important role in the epigenetic control of eukaryotic gene expression. The N-terminal tail of histone H3 binds to...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Bilgin et al. (2025) studied this question.

synapsesocial.com/papers/6930e8dbea1aef094cca3cba https://doi.org/10.1039/d5sc08094k

View Full Paper

Ask AI

Bookmark

Share

Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7

Key Points

Implication

Abstract

Discussion

Cite This Study

Stapled histone H3 tails are super-substrates for lysine methyltransferase SETD7

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading