December 4, 2025BiomedicinesOpen Access

The Role of Microsatellite Instability in Endometrial Hyperplasia and Risk of Carcinoma Development

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Analysis shows MMR protein loss in endometrial hyperplasia indicates potential carcinoma progression, suggesting MSI's role in cancer pathways.

Endometrial hyperplasia with MMR protein loss suggests a progression towards carcinoma.
Total loss of MMR proteins occurred in 10.7% of atypical hyperplasia cases examined.
Immunohistochemical analysis evaluated the expression of MMR proteins in endometrial hyperplasia.
Findings may support genetic counseling for hereditary cancer risks associated with MSI.

Mollova-Kyosebekirova et al. (2025) studied this question.

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Analysis shows MMR protein loss in endometrial hyperplasia indicates potential carcinoma progression, suggesting MSI's role in cancer pathways.