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December 4, 2025Alzheimer s Research & TherapyOpen Access

Optimizing tACS for working memory: differential outcomes in healthy aging and non-amnestic mild cognitive impairment

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Authors

KMKristína MitterováMPMonika PupíkováMGMartin Gajdoš

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Overview

Investigating theta tACS effects on working memory performance in healthy aging and non-amnestic MCI, suggesting optimal stimulation varies by cognitive load.

Key Points

  • Working memory performance improved with theta tACS in healthy aging subjects, indicating effective stimulation strategies.
  • Significant changes in accuracy and reaction times were noted in different cognitive loads, revealing tailored approaches are beneficial.
  • Single-blinded, repeated-measures design was applied with stimulation durations of 20 minutes to assess cognitive performance enhancements.
  • Findings imply that optimal tACS conditions may differ for MCI subjects due to variability in cognitive functions across populations.

Cite This Study

Mitterová et al. (2025) studied this question.

synapsesocial.com/papers/6930e8dbea1aef094cca3d25https://doi.org/10.1186/s13195-025-01922-4
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