Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 5, 2025Frontiers in ImmunologyOpen Access

Decoding m6A readers: roles of YTHDF proteins in leukemogenesis and cancer immunity

View Full Paper
Ask AI
Bookmark
Share

Authors

XJXiulin Jiang

Discussion

Loading...

Member takes

Overview

Review reveals cancer immunity roles of YTHDF proteins in leukemic stem cells and T cell activation.

Key Points

  • Tumor immunity is influenced by YTHDF proteins, enhancing immune checkpoint expression and T cell activation.
  • YTHDF proteins function in leukemic stem cells, contributing to tumor microenvironment adaptations.
  • Assessment of transcriptional gene regulation in leukemogenesis highlights roles of YTHDF1, YTHDF2, and YTHDF3.
  • Investigations suggest potential therapies targeting YTHDF may improve immune surveillance and therapeutic responses.

Cite This Study

Xiulin Jiang (2025) studied this question.

synapsesocial.com/papers/693231118e51979591dcdfefhttps://doi.org/10.3389/fimmu.2025.1692608
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hematopoietic stem cells: self-renewal and expansion2019 · 19 citations
  2. 2Tumor immune microenvironment lncRNAs2021 · 277 citations
  3. 3Immunosuppressive Agents and Infectious Risk in Transplantation: Managing the “Net State of Immunosuppression”2020 · 276 citations
  4. 4N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis2024 · 6 citations
  5. 5YTHDF2: a key RNA reader and antitumor target2025 · 31 citations