Observational analysis reduced epileptic seizures in acute epilepsy mouse models, indicating vitamin D may influence autophagy regulation.
(1) PTZ-induced seizures increased CaSR and decreased PTEN, triggering autophagy and worsening symptoms. (2) KA-induced epilepsy caused more severe damage with stronger autophagy activation. (3) VitD pretreatment mitigated seizures by modulating CaSR, PTEN, and autophagy, showing greater efficacy in the PTZ model.
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Li et al. (2025) studied this question.
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