Analysis reveals normal pDC functionality with decreased quantities in patients with primary Sjögren's syndrome, indicating excess IgG induces apoptosis.
Our data enhances the understanding of pDC functionality in pSS and the mechanisms of their abnormal reduction in peripheral blood. We first report that excess IgG induced pDC apoptosis via FcRn and promoted the reduction of peripheral pDCs in patients with pSS.
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Li et al. (2025) studied this question.
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