Synaptic Vesicle Exocytosis and Endocytosis in Motor Nerve Endings of Transgenic Mice Modeling Amyotrophic Lateral Sclerosis upon Antioxidant Treatment and Gene-Cell Therapy

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Experiments demonstrate endocytosis rates in ALS mice, suggesting GDNF's role in treatment efficacy.

Gene-cell therapy increased the rate of dye unloading due to synaptic vesicle exocytosis in motor nerve endings.
In experiments, the treatment did not significantly alter dye loading due to synaptic vesicle endocytosis.
Assessment used fluorescent dye loading in transgenic mice neurophysiological models of ALS.
Findings indicate that GDNF plays a significant role in enhancing synaptic functionality under specific therapies.

Grigoryev et al. (2025) studied this question.

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