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Case observations show pleuritis and cytopenias in elderly men, suggesting VEXAS syndrome may warrant corticosteroid therapy.
Elderly men with pleuritis, systemic inflammation, cytopenias, and bone‐marrow vacuolization may have VEXAS due to somatic UBA1 mutations. Pulmonary involvement, including pleuritis, can be a key presentation despite the absence of classic chondritis, and early recognition may enable timely initiation of corticosteroid therapy.
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Ito et al. (2025) studied this question.
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