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December 5, 2025NutrientsOpen Access

Fish Oil Present in High-Fat Diet, Unlike Other Fats, Attenuates Oxidative Stress and Activates Autophagy in Murine Adipose Tissue

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Authors

KCKarolina CiesielskaJWJacek WilczakAPAdam Prostek

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Overview

High-fat diet affects body mass and autophagy in C57BL/6J mice, suggesting fish oil may mitigate oxidative stress and promote cellular health.

Key Points

  • Fish oil in a high-fat diet decreases oxidative stress while enhancing autophagy in adipose tissue.
  • Mice exhibited increased body mass and altered adipose tissue characteristics after dietary changes over 15 weeks.
  • Observational analysis identified significant shifts in autophagy markers, particularly in visceral adipose tissue.
  • Results suggest dietary fat type influences metabolic health, highlighting the role of fish oil in reducing obesity-related damage.

Cite This Study

Ciesielska et al. (2025) studied this question.

synapsesocial.com/papers/693231308e51979591dce8a2https://doi.org/10.3390/nu17233776
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