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October 15, 2025Open Access

A high-fat diet enriched with fish oil affects metabolic pathways in the hypothalamus of rats: a proteomic approach

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Authors

ASAdriana Pereira de SouzaAPAmanda Paula PedrosoMAMaria Claudina Camargo de Andrade

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Overview

Proteomic analysis shows a high-fat fish oil diet alters metabolic pathways in the hypothalamus, suggesting potential health risks.

Key Points

  • Intake of a high-fat fish oil diet affects protein expression in rat hypothalamus, indicating metabolic alterations.
  • Twenty-nine proteins were significantly altered, with 15 down-regulated and 14 up-regulated, emphasizing dietary impacts.
  • Pathway-enrichment analysis linked proteins to carbohydrate metabolism and TCA cycle, highlighting metabolic consequences.
  • Long-term excess consumption of fish oil may lead to harmful effects in the hypothalamus, despite its known health benefits.

Cite This Study

Souza et al. (2025) studied this question.

synapsesocial.com/papers/68efbd16d61273c8652d7fc4https://doi.org/10.20935/acadnutr7929
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fish Oil Alters the Metabolome, Antioxidative Potential, and Secretory Profile of Visceral Adipose Tissue in Mice with High-Fat Diet-Induced Obesity Compared with Other Dietary Fat Sources2026
  2. 2Fish Oil Present in High-Fat Diet, Unlike Other Fats, Attenuates Oxidative Stress and Activates Autophagy in Murine Adipose Tissue2025
  3. 3The Role of Fish Oil in Modulating Metabolic Disorders: Implications for Cardiovascular Health, Endothelial Dysfunction Biomarkers, and Hypercholesterolemia2026
  4. 4Comparative Study of Hepatic Fatty Acid Composition and Lipid Profile in Rats Fed Diets Rich in Palm Oil, Olive Oil, and Lard2025
  5. 5Fish Oil Supplementation Mitigates High-Fat Diet-Induced Obesity: Exploring Epigenetic Modulation and Genes Associated with Adipose Tissue Dysfunction in Mice2024 · 4 citations