Findings reveal that FOXO3 activation of SIRT2 reduces myocardial injury by inhibiting NLPR3 inflammasome signaling pathway, suggesting new treatment strategies.
FOXO3 activates SIRT2 expression and inhibits NLPR3 inflammasome signaling pathway, thus alleviating MI/R injury. This study may offer a novel molecular target for the management of MI/R injury.
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Wang et al. (2025) studied this question.
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