Ir-Catalyzed Asymmetric Formal (3+2) Cycloaddition of Esters with Vinylcyclopropanes

Guorong Xiao; Mengjiao Yang; Duanyang Kong

doi:10.1039/d5ob01759a

January 1, 2025Organic & Biomolecular Chemistry

Ir-Catalyzed Asymmetric Formal (3+2) Cycloaddition of Esters with Vinylcyclopropanes

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Key Points

Asymmetric formal (3+2) cycloaddition generates key chiral tetrahydrofurans.
This reaction underscores the importance of stereoselective synthesis, producing compounds essential for pharmaceuticals.
Ir-catalyzed methods enhance reaction efficiency while creating complex products from simple esters.
These findings may enable advancements in the production of natural products and medicinal compounds.

Implication

Ir-catalyzed asymmetric formal (3+2) cycloaddition produces chiral tetrahydrofurans, indicating its significance for pharmaceuticals.

Abstract

Chiral polysubstituted tetrahydrofurans are key motifs in natural products and pharmaceuticals, and the stereoselective assembly of these architectures is of great importance. Herein, we report an Ir-catalyzed asymmetric formal (3+2)...

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Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/693231368e51979591dceb74 https://doi.org/10.1039/d5ob01759a

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Ir-Catalyzed Asymmetric Formal (3+2) Cycloaddition of Esters with Vinylcyclopropanes

Key Points

Implication

Abstract

Discussion

Cite This Study

Ir-Catalyzed Asymmetric Formal (3+2) Cycloaddition of Esters with Vinylcyclopropanes

Key Points

Implication

Abstract

Discussion

Cite This Study

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