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This is a In Vitro Study study.

December 5, 2025MoleculesOpen Access

Ergothioneine: An Antioxidative, Neuroprotective and Anti-Inflammatory Compound from Mushroom Residuals

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Ergothioneine demonstrates neuroprotective and anti-inflammatory activities, reducing oxidative damage and inflammation.
Cognitive decline and dementia correlate with low blood ergothioneine levels, supporting its micronutrient role.
Analysis of mushroom processing and extraction methods shows feasible sources for ergothioneine in dietary supplements.
Though standardization challenges exist, enhancing ergothioneine availability promotes therapeutic options for neurodegeneration.

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In vitro evidence shows ergothioneine improves neuroprotection against cognitive decline, indicating dietary supplements may help prevent dementia.

Harasym et al. (2025) studied this question.

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In vitro evidence shows ergothioneine improves neuroprotection against cognitive decline, indicating dietary supplements may help prevent dementia.