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December 6, 2025npj Metabolic Health and DiseaseOpen Access

Central cytometabolic functional vascular coupling in health and disease

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Authors

SSStuart SimsBWBlaine E. WeissRLRuei‐Lung Lin

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Overview

Review highlights the neurovascular unit's role in functional hyperemia, focusing on neurotransmitters and homeostasis.

Key Points

  • Functional hyperemia is orchestrated by complex interactions among cell types in the neurovascular unit, involving neurotransmitters.
  • Key modulators affect homeostasis, influencing vascular responses in both health and disease conditions.
  • Review highlights dynamic signaling within the neurovascular unit across different physiological states.
  • Understanding these processes could lead to improved therapies for neurovascular disorders.

Cite This Study

Sims et al. (2025) studied this question.

synapsesocial.com/papers/69337cceb3f947a0a1259bf1https://doi.org/10.1038/s44324-025-00090-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physiological Regulatory Mechanisms of Neurovascular Coupling and the Role of Its Dysfunction in Neurological Diseases2026 · 1 citations
  2. 2Neurovascular Coupling in Neurological Disorders: A Comprehensive Review2025
  3. 3Autoregulation of the Human Cerebrovasculature by Neurovascular Coupling2013
  4. 4Neurovascular coupling in humans: Physiology, methodological advances and clinical implications2015 · 493 citations
  5. 5A brain vascular electrical network links capillary pericytes to arterioles and is recruited for neurovascular coupling2024