Literature review on primary central nervous system lymphoma reveals key prognostic factors and treatment strategies, indicating challenges in studying rare tumors.
Primary central nervous system lymphoma is a rare type of extranodal non-Hodgkin’s lymphoma that occurs primarily in the central nervous system and represented by diffuse B-cell large cell lymphoma. Despite the fact that this tumor has been known for almost 100 years, studying it is difficult due to the rarity and, consequently, the limited number of statistically significant samples for research. This review analyzes the available literature data on the biological features of primary central nervous system lymphomas, pathogenesis and tumor microenvironment. In addition, we analyzed prognostic factors and current treatment strategies. The objective of this review is to determine the prospects for further study of this tumor.
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E.E. Dyachuk (2025) studied this question.
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