December 6, 2025BioengineeringOpen Access

Unsaturation-Driven Modulation of Antioxidant and Acetylcholinesterase Inhibitory Activities of Cardanol Derivatives

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Discussion

Research uncovers cardanol's antioxidant potential and acetylcholinesterase inhibition, indicating promise for neurodegenerative diseases.

C3 exhibited the highest antioxidant potential with an IC50 of 0.179 mg/mL, signaling effectiveness against oxidative stress.
3-[(8E,11E,14E)-8,11,14-pentadecatrien-1-yl] phenol showed the most pronounced inhibition of acetylcholinesterase activity.
Analysis involved molecular docking and dynamics studies, supporting interaction with AChE's catalytic active and peripheral anionic sites.
Findings suggest cardanol derivatives as candidates for new materials in combating oxidative stress and neurodegenerative diseases.

Martins et al. (2025) studied this question.

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Research uncovers cardanol's antioxidant potential and acetylcholinesterase inhibition, indicating promise for neurodegenerative diseases.