December 6, 2025Nature CommunicationsOpen Access

ctDNA detectability and representativeness in seven body liquids from patients with metastatic breast cancer

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ctDNA was frequently detected in blood and varied across body fluids, indicating diverse site representativeness.
Liquid biopsies utilizing low-pass whole genome sequencing can provide insights into cancer dynamics, enhancing diagnostics.
Phylogenetic reconstruction highlights differences in ctDNA detectability among ascites, saliva, and cerebrospinal fluid for metastatic sites.
Study results emphasize the clinical value of analyzing multiple body fluids for improved metastatic cancer characterization.

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Implication

Analysis shows circulating tumor DNA is found in various body fluids, suggesting a multi-fluid approach may improve monitoring of metastatic breast cancer.

Cite This Study

Richard et al. (2025) studied this question.

synapsesocial.com/papers/69337cdbb3f947a0a1259e6d https://doi.org/10.1038/s41467-025-65838-1

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Implication

Analysis shows circulating tumor DNA is found in various body fluids, suggesting a multi-fluid approach may improve monitoring of metastatic breast cancer.

ctDNA detectability and representativeness in seven body liquids from patients with metastatic breast cancer

Key Points

Discussion

Implication

Cite This Study

ctDNA detectability and representativeness in seven body liquids from patients with metastatic breast cancer

Key Points

Discussion

Implication

Cite This Study

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