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December 6, 2025Biology of Reproduction

Postnatal High-Fat Diet Consumption by Male Rat Offspring of Obese Mothers Accentuates Negative Outcomes of Reproductive Function in Young Adults

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Authors

DMDayana Méndez-SánchezLRLuis A. Reyes‐CastroGHGabriela Hernández‐Silva

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Overview

Experimental analysis shows decreased fertility in male rats, indicating maternal obesity coupled with high-fat diet exacerbates reproductive function.

Key Points

  • Fertility decreased significantly in male offspring exposed to maternal obesity and high-fat diet.
  • Malondialdehyde and reactive oxygen species levels increased in the testis of male rats, indicating oxidative stress.
  • Observational analysis revealed alterations in sperm motility and increased DNA fragmentation due to dietary influences.
  • These findings highlight how maternal obesity and environmental factors may lead to serious reproductive health issues.

Cite This Study

Méndez-Sánchez et al. (2025) studied this question.

synapsesocial.com/papers/69337cdbb3f947a0a1259ec0https://doi.org/10.1093/biolre/ioaf261
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