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This is a In Vitro Study study.

December 6, 2025eLifeOpen Access

Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

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Cortical neurons derived from induced pluripotent stem cells show diverse gene expression and cellular features.
Analysis involves 60,000 single-cell RNA-sequencing samples across three neurodevelopmental time points.
Assessment of cell morphology utilizing Cell Painting complements transcriptomic insights, emphasizing mitochondrial function.
Findings reveal significant morphologies associated with neurodevelopmental disorders, such as Kabuki syndrome.

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Implication

Joint analysis of gene expression and morphology in differentiated iPSC-derived cortical neurons indicates potential relevance to neurodevelopmental disorders.

Cite This Study

Meistermann et al. (2025) studied this question.

synapsesocial.com/papers/69337cdbb3f947a0a1259ee0 https://doi.org/10.7554/elife.102578

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Implication

Joint analysis of gene expression and morphology in differentiated iPSC-derived cortical neurons indicates potential relevance to neurodevelopmental disorders.

Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

Key Points

Discussion

Implication

Cite This Study

Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

Key Points

Discussion

Implication

Cite This Study