Tumor microenvironment-responsive COF-based core-shell cascade nanoreactor with photocatalytic H 2 O 2 self-supply for improved treatment

Wen-Xiu Ren; Lili Tong; Jie Feng

doi:10.1039/d5cc06338h

December 2, 2025Chemical Communications

Tumor microenvironment-responsive COF-based core-shell cascade nanoreactor with photocatalytic H 2 O 2 self-supply for improved treatment

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Key Points

Treatment efficacy improves through enhanced antitumor therapy using tumor microenvironment-responsive mechanisms.
Key mechanisms include glutathione depletion and photocatalytic H2O2 self-supply methods.
Covalent organic frameworks support the structure of the designed nanoreactor, ensuring stability and effectiveness.
Supports the use of a novel nanoreactor approach for improved treatments in complex tumor environments.

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Implication

This nanoreactor improves antitumor therapy by utilizing photocatalytic H2O2, indicating potential in tumor microenvironments.

Abstract

A smart tumor-responsive core-shell nanoreactor (Cu@Hemin@COF@PDA) based on covalent organic frameworks (COFs) was designed. It enhances antitumor therapy through photocatalytic H₂O₂ self-supply, glutathione (GSH) depletion via Cu²⁺/Cu⁺ conversion, and integrated...

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Cite This Study

Ren et al. (2025) studied this question.

synapsesocial.com/papers/69337cdbb3f947a0a1259f3b https://doi.org/10.1039/d5cc06338h

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Tumor microenvironment-responsive COF-based core-shell cascade nanoreactor with photocatalytic H 2 O 2 self-supply for improved treatment

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Tumor microenvironment-responsive COF-based core-shell cascade nanoreactor with photocatalytic H 2 O 2 self-supply for improved treatment

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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