Analysis shows diminished isoleucine in cancer cells, indicating LAT1-targeted therapies may enhance anti-cancer effects.
Reductions in valine and isoleucine in cancer cells primarily account for the multifaceted anti-cancer pharmacological activities of LAT1 inhibition by nanvuranlat. This study establishes the molecular basis for LAT1-targeted therapy and highlights growth-promoting processes in cancer cells that can be exploited pharmacologically by modulating the availability of specific amino acids.
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Kou Nishikubo (2025) studied this question.