Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne: A Pooled Analysis by Age

Leon Kircik; Lawrence F. Eichenfield; Emmy Graber

doi:10.36849/jdd.9407

November 1, 2025Journal of Drugs in Dermatology

Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne: A Pooled Analysis by Age

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Key Points

Approximately 50% of participants achieved clear or almost clear skin, highlighting the gel's effectiveness.
More than 70% reductions in lesion counts were observed, showcasing substantial improvement across the participant group.
Fixed-dose, triple-combination gel assessed in varied age groups demonstrates broad applicability and tolerability.
Efficacy and tolerance confirm that this treatment may be suitable for managing moderate-to-severe acne effectively across demographics.

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Implication

Pooled analysis shows fixed-dose gel improves acne severity in all ages, indicating a viable treatment option for diverse populations.

Abstract

Fixed-dose, triple-combination CAB gel was efficacious and well tolerated in participants with moderate-to-severe acne, regardless of age. Approximately half of the participants achieved clear/almost clear skin, with >70% reductions in lesion counts.

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Kircik et al. (2025) studied this question.

synapsesocial.com/papers/69337ce8b3f947a0a125a10f https://doi.org/10.36849/jdd.9407

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Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne: A Pooled Analysis by Age

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne: A Pooled Analysis by Age

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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